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The mechanism likely involves stress reduction (lowering cortisol that suppresses BDNF) combined with attentional training that directly engages BDNF-dependent hippocampal and prefrontal circuits

*Contraindications weight loss injections include a personal or family history of medullary thyroid cancer, allergy to GLP-1 and weight loss injections, Type 1 Diabetes or history of Diabetic Ketoacidosis, personal or family history of Multiple Endocrine Neoplasia, personal history of Pancreatitis, renal impairment or kidney disease, gallbladder disease, or concurrent use of anti-diabetic medications or insulin

Another consideration is heat build up in the motor and speed control over such a long run

How Common Is Feeling Cold on Ozempic